Seed Extract and Fractions of Telfairia OccidentalisAttenuated Doxorubicin-Induced Testiculotoxicity in Rats
Doxorubicin, an anthracycline glycoside antibiotic with broad-spectrum of activity against various human solid tumors and hematological malignancies [7], but limited clinical usefulness due to its diverse toxicities, including cardiac, hepatic, hematological, and testicular toxicity [58]. The toxic, short-lived metabolite, semiquinone form of doxorubicin, triggers the generation of reactive oxygen species (ROS) through cascades of events. […]